The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias. Olanzapine is not approved by the FDA for use in the treatment of behavioral disorders in elderly patients with dementia. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.
Zyprexa IntraMuscular should be reconstituted only with Sterile Water for Injection. Zyprexa IntraMuscular should not be combined in a syringe with diazepam injection because precipitation occurs when these products are mixed. Lorazepam injection should not be used to reconstitute Zyprexa IntraMuscular as this combination results in a delayed reconstitution time. Zyprexa IntraMuscular should not be combined in a syringe with haloperidol injection because the resulting low pH has been shown to degrade olanzapine over time. This medication may rarely cause a very serious condition called NMS. Thus, it is recommended that patients requiring subsequent intramuscular injections be assessed for orthostatic hypotension prior to the administration of any subsequent doses of intramuscular olanzapine for injection. The administration of an additional dose to a patient with a clinically significant postural change in systolic blood pressure is not recommended.
Olanzapine's specific metabolic profile is presented below. The recommended starting dose of Zyprexa tablets depends on the disease being treated: 10 mg per day is used in schizophrenia and in the prevention of manic episodes, and 15 mg per day in the treatment of manic episodes, unless it is used with other medicines, in which case the starting dose can be 10 mg per day. The dose is adjusted according to how well the patient responds to and tolerates the treatment. The usual dose range is between 5 and 20 mg per day. Japanese, Chinese and Caucasians, especially after normalization for body weight differences. Dosage modifications for race are, therefore, not recommended.
HCl is a fixed-dose combination of Zyprexa and fluoxetine. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Zyprexa Relprevv is indicated for the treatment of schizophrenia.
Smiths Medical ASD, Inc. Oral carcinogenicity studies were conducted in mice and rats. Inactive ingredients are carnauba wax, crospovidone, hydroxypropyl cellulose, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, and other inactive ingredients. The term sinus congestion was combined under nasal congestion. TD and are considered the drugs of choice in patients being treated for psychosis. Other common side effects in teenagers 13-17 years old include: headache, stomach-area abdominal pain, pain in your arms or legs, or tiredness. Teenagers experienced greater increases in prolactin, liver enzymes, and sleepiness, as compared with adults. The chronic use of neuroleptic agents can cause persistent elevations in prolactin levels due to antagonism of dopamine D2 receptors. Based on in vitro data, approximately one-third of human breast cancers are thought to be prolactin-dependent. The clinical significance of this observation with respect to long-term neuroleptic therapy is unknown. Chronic administration of neuroleptic drugs has been associated with mammary tumorigenesis in rodent studies but not in human clinical or epidemiologic studies. Until further data are available, therapy with neuroleptic agents should be administered cautiously in patients with a previously detected breast cancer. Caution is also advised in patients with preexisting hyperprolactinemia. Hyperprolactinemia may suppress hypothalamic gonadotrophin releasing hormone GnRH resulting in reduced pituitary gonadotropin secretion. This, in turn, may inhibit reproductive function by impairing gonadal steroidogenesis in both female and male patients. Galactorrhea, amenorrhea, gynecomastia, and impotence have been reported in patients receiving prolactin-elevating compounds; however, the clinical significance of elevated serum prolactin levels is unknown for most patients. Long-standing hyperprolactinemia when associated with hypogonadism may lead to decreased bone density in both female and male patients. Eli Lilly and Company. Drowsiness, confusion, and dizziness can increase the risk of falling. How should I take Zyprexa? Therefore, concomitant olanzapine administration does not require dosage adjustment of valproate.
Prescribers or other health professionals should inform patients, their families, and their caregivers about the potential benefits and potential risks associated with treatment with Zyprexa Relprevv, and should counsel them in its appropriate use. A patient Medication Guide is available for Zyprexa Relprevv. Prescribers or other health professionals should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. Patients should be advised of the following issues and asked to alert their prescriber if these occur while taking Zyprexa as monotherapy or in combination with fluoxetine. If you do not think you are getting better or have any concerns about your condition while taking Zyprexa, call your doctor. When using Zyprexa and fluoxetine in combination, also refer to the Patient Counseling Information section of the package insert for Symbyax. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. For deep intramuscular gluteal injection only. Not to be injected intravenously or subcutaneously. This medication is given by injection into the buttock muscle by a professional as directed by your doctor, usually every 2 to 4 weeks. When stopping abruptly, discontinuation symptoms such as sweating, insomnia, tremor, anxiety, nausea, and vomiting, have been reported. Read the Guide provided by your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply. While there is no body of evidence available to answer the question of how long the adolescent patient treated with Zyprexa should be maintained, maintenance efficacy can be extrapolated from adult data along with comparisons of olanzapine pharmacokinetic parameters in adult and adolescent patients. It is generally recommended that responding patients be continued beyond the acute response, but at the lowest dose needed to maintain remission. Patients should be periodically reassessed to determine the need for maintenance treatment. If you develop any of these symptoms, tell your doctor right away. In pooled studies of adults as well as pooled studies of adolescents, there were no significant differences between olanzapine and placebo in the proportions of patients experiencing potentially important changes in ECG parameters, including QT, QTc Fridericia corrected and PR intervals. divalproex
DSM-IV or DSM-IV-TR criteria for schizophrenia. It includes a needle and needle safety sheath. The data in each column represent data for those patients who completed treatment periods of the durations specified. Little clinical trial data is available on weight gain in adolescents with olanzapine beyond 6 months of treatment. Zyprexa Relprevv-treated; 0% placebo-treated. Efficacy was established in three clinical trials in adult patients with manic or mixed episodes of bipolar I disorder: two 3- to 4-week trials and one monotherapy maintenance trial. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. tekz.info amitriptyline
These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations. The effect of olanzapine on labor and delivery in humans is unknown. Parturition in rats was not affected by olanzapine. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. While there is no body of evidence to answer the question of how long a patient treated with Zyprexa and fluoxetine in combination should remain on it, it is generally accepted that treatment resistant depression major depressive disorder in adult patients who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode is a chronic illness requiring chronic treatment. The physician should periodically reexamine the need for continued pharmacotherapy. LILLY and tablet number. Your doctor should do tests to check your blood sugar before you start taking Zyprexa Relprevv and during treatment. In people who do not have diabetes, sometimes high blood sugar goes away when Zyprexa Relprevv is stopped. People with diabetes and some people who did not have diabetes before taking Zyprexa Relprevv need to take medicine for high blood sugar even after they stop taking Zyprexa Relprevv. Use with caution. This medicine may raise blood sugar levels. Although no controlled studies have been conducted to determine how long patients should be treated with Zyprexa Relprevv, efficacy has been demonstrated over a period of 24 weeks in patients with stabilized schizophrenia. Additionally, oral ZYPREXA has been shown to be effective in maintenance of treatment response in schizophrenia in longer-term use. Patients should be periodically reassessed to determine the need for continued treatment. Area under the curve achieved after an intramuscular dose is similar to that achieved after oral administration of the same dose. The half-life observed after intramuscular administration is similar to that observed after oral dosing. The pharmacokinetics are linear over the clinical dosing range. Metabolic profiles after intramuscular administration are qualitatively similar to metabolic profiles after oral administration. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.
Digestive System - Infrequent: nausea. When you leave the clinic, someone must be with you. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. CYP mediated oxidation are the primary metabolic pathways for olanzapine. Zyprexa Relprevv and have their WBC followed until recovery. Disorders - Infrequent: creatine phosphokinase increased. Weight gain. Weight gain is very common in people who take Zyprexa. Teenagers 13 to 17 years old are more likely to gain weight and to gain more weight than adults. Children 10 to 17 years old are also more likely to gain weight and to gain more weight than adults when Zyprexa is used in combination with fluoxetine. Some people may gain a lot of weight while taking Zyprexa, so you and your doctor should check your weight regularly. Talk to your doctor about ways to control weight gain, such as eating a healthy, balanced diet, and exercising. Zyprexa be given marketing authorisation. In analyses of patients who completed 9-12 months of olanzapine therapy, mean change in fasting and nonfasting glucose levels continued to increase over time. Talk with your doctor before you use medicines that may cause drowsiness eg, sleep aids, muscle relaxers while you are using Zyprexa Intramuscular; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. lopid
NOT TO BE INJECTED INTRAVENOUSLY OR SUBCUTANEOUSLY. Somnolence was reported in 8% of patients receiving IM extended-release suspension. The possibility of a suicide attempt is inherent in schizophrenia, and close supervision of high-risk patients should accompany drug therapy. April 2003 about the use of their drug and the increased risk of among elderly people with dementia. If you currently have, or have had any problems in the past with addictive drugs, including street drugs and medication, you should talk with your doctor before you take this medication. You should also mention any serious reactions you may have had to other similar medications. If you are taking other prescription drugs or supplements, you should check with your doctor or pharmacist before taking this drug. Zyprexa Relprevv and with incidence greater than placebo who participated in the 8-week, placebo-controlled trial. The combined effects of age, smoking, and gender could lead to substantial pharmacokinetic differences in populations. The clearance in young smoking males, for example, may be 3 times higher than that in elderly nonsmoking females. Zyprexa tablets are intended for oral administration only. It is not known if Zyprexa Relprevv will harm your unborn baby. At first, 10 to 15 milligrams mg once a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day. If agitation warranting additional intramuscular doses persists following the initial dose, subsequent doses up to 10 mg may be given. However, the efficacy of repeated doses of intramuscular olanzapine for injection in agitated patients has not been systematically evaluated in controlled clinical trials. Also, the safety of total daily doses greater than 30 mg, or 10 mg injections given more frequently than 2 hours after the initial dose, and 4 hours after the second dose have not been evaluated in clinical trials. pharmacy valtrex junior
Tolerance of oral ZYPREXA should be established prior to initiating treatment with Zyprexa Relprevv. Concomitant administration of intramuscular olanzapine and parenteral benzodiazepine is not recommended due to the potential for excessive sedation and cardiorespiratory depression. Nausea and dry mouth have been reported to be dose related. Select and prepare a site for injection in the gluteal area. Our Zyprexa Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Zyprexa Relprevv includes a vial of the drug product and a vial of the sterile diluent for Zyprexa Relprevv. If you have any questions about Zyprexa Intramuscular, please talk with your doctor, pharmacist, or other health care provider. Post-injection Delirium Sedation Syndrome PDSS. PDSS is a serious problem that can happen after you get a Zyprexa Relprevv injection if the medicine gets in your blood too fast. If your symptoms do not improve or if they become worse, check with your doctor. The term tension headache was combined under headache. Olanzapine belongs to a class of drugs called atypical antipsychotics. Olanzapine, because of its potential for inducing hypotension, may enhance the effects of certain antihypertensive agents.
PANSS total score also on the extracted BPRS total on the BPRS psychosis cluster, on the PANSS Negative subscale, and on CGI Severity. What happens if I miss a dose Zyprexa, Zyprexa Zydis? Avoid drinking alcohol while taking Zyprexa Relprevv. Drinking alcohol while you take Zyprexa Relprevv may make you sleepier than if you take Zyprexa Relprevv alone. Avoid doing things that may cause you to overheat, such as hard work or in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Remove by grasping the Luer hub of the needle protection device with thumb and forefinger, keeping the free fingers clear of the end of the device containing the needle point. purchase generic proscar mastercard
Atypical antipsychotic drugs have been associated with metabolic changes including hyperglycemia, dyslipidemia, and weight gain. Withdraw air to equalize the pressure in the vial by pulling back slightly on the plunger in the syringe. For both oral ZYPREXA and Zyprexa Relprevv higher average plasma concentrations of olanzapine were observed in women than in men. There were, however, no apparent differences between men and women in effectiveness or adverse effects. Dosage modifications based on gender should not be needed. Zyprexa. Agranulocytosis has also been reported. The proportion of patients who had changes at least once in total cholesterol, LDL cholesterol or triglycerides from normal or borderline to high, or changes in HDL cholesterol from normal or borderline to low, was greater in long-term studies at least 48 weeks as compared with short-term studies. shows categorical changes in fasting lipids values. Alzheimer's dementia. Olanzapine is not approved for the treatment of patients with Alzheimer's disease. Conditions that lower the seizure threshold may be more prevalent in a population of 65 years or older. Zyprexa Relprevv. Zyprexa Relprevv must be administered in a registered healthcare facility with ready access to emergency response services. After each injection, patients must be observed at the healthcare facility by a healthcare professional for at least 3 hours. Some medical conditions may interact with Zyprexa Intramuscular. Zyprexa Relprevv is an atypical antipsychotic that belongs to the thienobenzodiazepine class. To help prevent clogging, a 19-gauge or larger needle must be used. See “What is the most important information I should know about Zyprexa? Safety and efficacy of Zyprexa and fluoxetine in combination was determined in clinical trials supporting approval of Symbyax fixed dose combination of Zyprexa and fluoxetine. Take Zyprexa exactly as prescribed. Your doctor may need to change adjust the dose of Zyprexa until it is right for you. SOME EXCESS PRODUCT WILL REMAIN IN THE VIAL. Avoid smoking cigarettes and using tobacco products as they may interfere with the effectiveness of this drug. Hypodermic Needle-Pro needle with needle protection device. where can i promethazine gels
Have someone drive you home after your injection. You must be enrolled in a special program to receive these injections. Only doctors, facilities, and pharmacies also enrolled in this program may prescribe, inject, or provide this to patients. Talk with your doctor about the risks and benefits of this medication and other treatment choices. In clinical studies, changes in prolactin levels were found to be statistically significantly different based on dose, higher doses were associated with higher levels of prolactin. In a study of up to 12 weeks, plasma prolactin concentrations exceeded the upper limit of normal ULN in approximately 30% of patients who had normal baseline prolactin values. The majority of these elevations were mild, and remained below 2 x ULN. Olanzapine may cause drowsiness, trouble with thinking, trouble with controlling body movements, or trouble with your vision, which may lead to falls, fractures or other injuries. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well. Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents. Olanzapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using olanzapine. Remove the needle from the vial, holding the vial upright to prevent any loss of material. People taking this medication may overheat more easily and may have trouble cooling down after strenuous physical activity. Avoid dehydration, especially during hot weather or when exercising. If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions. Contact your doctor right away if you think you may be dehydrated.
Do not take other medicines unless they have been discussed with your doctor. AST and hepatic enzyme were combined under liver enzymes. Approximately 50% of the patients had discontinued from the olanzapine group by day 59 and 50% of the placebo group had discontinued by day 23 of double-blind treatment. Zyprexa Relprevv is a long-acting form of olanzapine and is intended for deep intramuscular gluteal injection only. Zyprexa Relprevv treatment. Your doctor will talk to you about the risks and benefits of Zyprexa Relprevv treatment. cheapest tinidazole order online shopping
The physician should periodically reexamine the need for continued pharmacotherapy. All doses were statistically superior to placebo on the PANSS Excited Component at 2 hours post-injection. However, the effect was larger and more consistent for the 3 highest doses. Inject the diluent into the powder vial. Before using olanzapine, tell your doctor if you regularly use other medicines that can make you sleepy or slow your breathing such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety. They can add to the side effects of olanzapine. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Use Zyprexa Intramuscular as directed by your doctor. Check the label on the medicine for exact dosing instructions. Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic treatment, which patients are likely to develop the syndrome. Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown. Tell your surgeon or anesthesiologist that you are taking this medication if you plan to have any type of surgery, including oral surgery. Keep Zyprexa and all medicines out of the reach of children. Safety of co-administration of doses above 18 mg olanzapine with 75 mg fluoxetine has not been evaluated in clinical studies. If foam forms, let vial stand to allow foam to dissipate. This increase is likely due to the fact that carbamazepine is a potent inducer of CYP1A2 activity. Higher daily doses of carbamazepine may cause an even greater increase in olanzapine clearance. In patients who do require chronic treatment, the smallest dose and the shortest duration of treatment producing a satisfactory clinical response should be sought. The need for continued treatment should be reassessed periodically. Zyprexa Relprevv Patient Care Program. You must agree to the rules of the Zyprexa Relprevv Patient Care Program before you register. amoxicillin
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Co-administration of lorazepam does not significantly affect the pharmacokinetics of olanzapine, unconjugated lorazepam, or total lorazepam. However, this co-administration of lorazepam with olanzapine potentiated the somnolence observed with either drug alone. The combined effects of age, smoking, and gender could lead to substantial pharmacokinetic differences in populations. The medicine can only be obtained with a prescription. How is Zyprexa used? The possibility of multiple drug involvement should be considered. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation, which may include intubation. The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis. Cardiovascular monitoring should commence immediately and should include continuous electrocardiographic monitoring to detect possible arrhythmias.
Olanzapine is an antipsychotic medication that affects chemicals in the brain. Tell your doctor about all the medicines that you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Zyprexa and some medicines may interact with each other and may not work as well, or cause possible serious side effects. Your doctor can tell you if it is safe to take Zyprexa with your other medicines. Do not start or stop any medicine while taking Zyprexa without talking to your doctor first. When indicated, dose escalation should be performed with caution in these patients.
The prescriber should be aware that the figures in the tables and tabulations cannot be used to predict the incidence of side effects in the course of usual medical practice where patient characteristics and other factors differ from those that prevailed in the clinical trials. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. The cited figures, however, do provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the adverse reactions incidence in the population studied.
The risks of using olanzapine in combination with other drugs have not been extensively evaluated in systematic studies. High blood sugar hyperglycemia. High blood sugar can happen if you have diabetes already or if you have never had diabetes. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.